Alpha-Substitution Reactions in Carbonyl Compounds


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Alpha-Substitution Reactions in Carbonyl Compounds
1011303Alpha-Substitution Reactions in Carbonyl CompoundsA carbon atom bonded to either side of a carbonyl group is called an alpha (α) carbon. Hydrogen atoms bonded to α-carbons are called α-hydrogens. Alpha-substitution reactions involve the replacement of an α-hydrogen with an electrophile. Carbonyl compounds that undergo these reactions are aldehydes, ketones, esters, acids, and amides. This reaction is an important way of making new carbon-carbon bonds. Many new compounds can be prepared by these substitution reac…
Citation
Daniel R. Bloch: Organic Chemistry, Second edition. Alpha-Substitution Reactions in Carbonyl Compounds, Chapter (McGraw-Hill Professional, 2012), AccessEngineering Export