Carbonyl Condensation Reactions


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Carbonyl Condensation Reactions
1011303Carbonyl Condensation ReactionsCarbonyl compounds can act as nucleophiles or electrophiles. In carbonyl condensation reactions, one carbonyl compound reacts with base to form an enolate anion. This anion acts like a nucleophile attacking an electrophilic carbon atom in the carbonyl group of another molecule. The result is the formation of a new carbon–carbon bond between the carbonyl carbon atom of one molecule and the α-carbon atom of another carbonyl molecule. This is an example of an α-substitution reaction. Various carbonyl compounds can undergo these reactions, including aldehydes, ketones, esters, anhydrides, and amides. There are numerous biological reactions t…
Citation
Daniel R. Bloch: Organic Chemistry, Second edition. Carbonyl Condensation Reactions, Chapter (McGraw-Hill Professional, 2012), AccessEngineering Export