BIOREACTORS AND UPSTREAM PROCESSES


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BIOREACTORS AND UPSTREAM PROCESSES
BIOREACTORS AND UPSTREAM PROCESSESBioreactors play a variety of roles in biopharmaceutical production. Most importantly they produce the products, be they therapeutic proteins, vaccines, or whole-cell therapies. In most cases, the actual commercial production is achieved in a series of successively larger bioreactors until the final product production bioreactor is reached. Further, bioreactors are used to generate a “bank” of frozen cells which are later thawed to initiate a production run. Process characterization studies are carried out in scale-down reactors to satisfy regulatory requirements. Laboratory and pilot plant scale-down bioreactors are typically used to evaluate proposed changes to a commercial production process, to evaluate unusual processing events and excursions…
Citation
Dr. Don W. Green; Dr. Marylee Z. Southard: Perry's Chemical Engineers' Handbook, 9th Edition. BIOREACTORS AND UPSTREAM PROCESSES, Chapter (McGraw-Hill Professional, 2019), AccessEngineering Export